Feb 06, 2023, 12:55 pm
The US Geological Survey said the 7.8 magnitude tremor struck at 04:17 local time (01:17 GMT) at a depth of 17.9km (11 miles) near the city of Gaziantep.
In Turkey, officials confirmed more than 76 deaths so far and 10 cities hit, including Diyarbakir.
In Syria, more than 230 people were killed, state media reported.
The Syrian health ministry said people had died in the provinces of Aleppo, Latakia, Hama and Tartus.
There are fears the death toll will rise sharply in the coming hours.
Many buildings have collapsed and rescue teams have been deployed to search for survivors under huge piles of rubble.
Turkish Interior Minister Suleymon Soylu said 10 cities were affected: Gaziantep, Kahramanmaras, Hatay, Osmaniye, Adiyaman, Malatya, Sanliurfa, Adana, Diyarbakir and Kilis.
In Malatya province, north-east of Gaziantep, at least 23 people were killed, local officials said. In Sanliurfa, to the east, there were 17 deaths. And more deaths were reported in Diyarbakir and Osmaniye.
About 440 people were injured in Turkey and 639 in Syria.